September 1, 1992American Review of Respiratory Disease
Effect of Positive End-expiratory Pressure on Right Ventricular Function in Humans
Key result
Increasing positive end-expiratory pressure from 0 to 15 cm H2O significantly varied right ventricular end-diastolic volume for individuals (p < 0.05) independently of filling pressure changes.
Why the study?
Does increasing positive end-expiratory pressure (PEEP) alter right ventricular function and volumes in patients after thoracotomy?
Population
12 patients after thoracotomy
Comparison
Positive end-expiratory pressure increased from… vs Baseline (PEEP zero)
Design
Other
Authors
Discussion
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Implication
Alerts to RV volume monitoring during PEEP titration post-thoracotomy; leaves open preload-independent mechanisms in larger cohorts.
Study Design
Type
Observational (n=12)
Structured PICO
Does increasing positive end-expiratory pressure (PEEP) alter right ventricular function and volumes in patients after thoracotomy?
P
Population
12 patients after thoracotomy
I
Intervention
Positive end-expiratory pressure (PEEP) increased from zero to 15 cm H2O
C
Comparator
Baseline (PEEP zero)
O
Outcome
Right ventricular (RV) volumes, pressures, and pericardial pressure (Ppc)surrogate
Increasing PEEP in post-thoracotomy patients alters RV volumes independently of filling pressures, likely due to RV shape changes dissociating EDV from wall stress.
Cite This Study
Pinsky et al. (1992) conducted an observational in Post-thoracotomy (n=12). Positive end-expiratory pressure (PEEP) vs. Baseline (PEEP of 0 cm H2O) was evaluated on Right ventricular volumes, pressures, and pericardial pressure. Increasing positive end-expiratory pressure from 0 to 15 cm H2O significantly varied right ventricular end-diastolic volume for individuals (p < 0.05) independently of filling pressure changes.