Key result
Positive end-expiratory pressure (PEEP) decreased left ventricular stroke volume due to impaired LV filling (EDV reduced from 37.8 ml at baseline to 25.9 ml at 15 cm H2O; p<0.05).
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May warrant preload assessment before high PEEP in ventilated patients; leaves open optimal strategies in cardiac dysfunction.
Absolute Event Rate: 25.9% vs 37.8%
p-value: p=<0.05
Johnston et al. (1989) studied this question. Positive end-expiratory pressure (PEEP) vs. Zero PEEP (baseline) was evaluated on Left ventricular end-diastolic volume (EDV) (p=<0.05). Positive end-expiratory pressure (PEEP) decreased left ventricular stroke volume due to impaired LV filling (EDV reduced from 37.8 ml at baseline to 25.9 ml at 15 cm H2O; p<0.05).
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