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February 24, 2003CirculationOpen Access

Reduced Connexin43 Expression Inhibits Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor–Deficient Mice

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Authors

BKBrenda R. KwakGeneral / Preventive / Lipids NVNiels R. VeillardUniversity of Geneva GPGraziano PelliUniversity of Geneva

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Implication

Randomized trial shows reduced atherosclerotic lesions in LDL receptor-deficient mice with lower connexin43 expression, suggesting its vital role.

Key Points

This research investigates the role of connexin43 in the development of atherosclerosis.
Used LDL receptor-deficient mice with normal and reduced connexin43 levels on a cholesterol-rich diet for 14 weeks.
Examined atherosclerotic lesions for inflammatory cells and fibrous cap thickness.
Analyzed the effect of statins on connexin43 expression in primary human vascular cells in vitro.
Atherosclerosis was reduced by 50% in Cx43+/-LDLR-/- mice compared to Cx43+/+LDLR-/- controls (P<0.01).
Atheroma in Cx43+/-LDLR-/- mice had fewer inflammatory cells and thicker fibrous caps with more collagen.
Statin treatment in LDLR-/- mice also led to reduced connexin43 expression and exhibited thicker fibrous caps.

Cite This Study

Kwak et al. (2003) studied this question.

synapsesocial.com/papers/6a10020f2badbc352aff2392 https://doi.org/10.1161/01.cir.0000051364.70064.d1

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Rapid Turnover of Connexin43 in the Adult Rat Heart1998 · 442 citations
2Evidence for Increased Collagenolysis by Interstitial Collagenases-1 and -3 in Vulnerable Human Atheromatous Plaques1999 · 659 citations
3Connexin43 Gene Expression in the Rabbit Arterial Wall: Effects of Hypercholesterolemia, Balloon Injury and Their Combination2008 · 83 citations
4Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.1994 · 735 citations
5Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene2000 · 170 citations