Key result
A 1% cholesterol diet increased the expression of connexin43 and osteopontin mRNA levels in the aortic valves of male New Zealand rabbits compared to a normal chow diet.
Why the study?
Does a high-cholesterol diet increase the expression of connexin43 in the aortic valve of male New Zealand rabbits?
Population
20 male New Zealand rabbits
Comparison
Diet containing 1% cholesterol for 12 weeks vs Normal chow diet
Design
Preclinical
Follow-up
12 weeks
Authors
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High-cholesterol diet may alter rabbit aortic valve cell signaling; leaves open connexin43's role in human valve disease.
Does a high-cholesterol diet increase the expression of connexin43 in the aortic valve of male New Zealand rabbits?
Hypercholesterolemia increases connexin43 expression in the aortic valve of rabbits, suggesting altered cell-to-cell communication may contribute to aortic valve sclerosis.
Wang et al. (2009) studied Aortic valve sclerosis (n=20). 1% cholesterol diet vs. Normal chow diet was evaluated on Expression of connexin43 and osteopontin in the aortic valve. A 1% cholesterol diet increased the expression of connexin43 and osteopontin mRNA levels in the aortic valves of male New Zealand rabbits compared to a normal chow diet.
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