Key result
A cholesterol-enriched diet induced left ventricular diastolic dysfunction with preserved systolic function, cardiac inflammation, and oxidative stress in rabbits.
Why the study?
Animal models of left ventricular diastolic dysfunction are limited and underlying mechanisms remain largely unknown, prompting development of a rabbit model without aortic valve stenosis.
Does a cholesterol-enriched diet induce left ventricular diastolic dysfunction and cardiac inflammation in rabbits?
Comparison
Cholesterol-enriched diet vs normal diet
Design
Preclinical animal study
Follow-up
Average total diet duration: 20 weeks
Authors
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Supports rabbit model of diet-induced HFpEF; leaves open human translation.
Does a cholesterol-enriched diet induce left ventricular diastolic dysfunction and cardiac inflammation in rabbits?
p-value: p=<0.001
A cholesterol-enriched diet in rabbits successfully induces left ventricular diastolic dysfunction with preserved systolic function and cardiac inflammation, providing a novel preclinical model for HFpEF research.
Nachar et al. (2019) studied Left ventricular diastolic dysfunction (LVDD) (n=17). Cholesterol-enriched diet vs. Normal diet was evaluated on Left ventricular diastolic dysfunction defined by E/Em ratio higher than baseline mean + 2SD (p=<0.001). A cholesterol-enriched diet induced left ventricular diastolic dysfunction with preserved systolic function, cardiac inflammation, and oxidative stress in rabbits.
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