Population
Rabbit heart valves (atrioventricular and aortic) from rabbits fed a high-cholesterol diet
Design
Preclinical
Authors
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Premature for clinical lipid management; leaves open LDL-collagen binding as a driver of human intimal lipid aggregation.
This preclinical study demonstrates that LDL rapidly associates with collagen in the extracellular matrix of rabbit heart valves, suggesting a key step in intimal lipid aggregation.
Nievelstein-Post et al. (1994) studied this question.
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