Key result
In 29-day cholesterol-fed rabbits, extracellular liposomes in heart valves range from 23 to 220 nm, with a size distribution best explained by a model incorporating liposome fusing and merging.
Population
29-day cholesterol-fed rabbits
Design
Preclinical
Follow-up
29 days
Authors
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Findings in hyperlipidemic rabbits are hypothesis-generating; extends nucleation-polymerization models to valvular liposome growth but requires human validation.
Extracellular liposomes in heart valves of hyperlipidemic rabbits grow via fusing/merging, which can be accurately predicted by a modified nucleation-polymerization mathematical model.
Zeng et al. (2007) studied Hyperlipidemia. Cholesterol feeding was evaluated on Size distribution of extracellular liposomes. In 29-day cholesterol-fed rabbits, extracellular liposomes in heart valves range from 23 to 220 nm, with a size distribution best explained by a model incorporating liposome fusing and merging.
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