Key result
Experimental introduction of horseradish peroxidase in rat vessels demonstrated focal spot growth differences between atherosclerosis-resistant and disease-prone vessels.
Population
Rat vessel walls (pulmonary artery, inferior vena cava, aorta, carotid artery)
Comparison
Horseradish peroxidase (HRP) introduction vs Atherosclerosis resistant vs. disease prone…
Design
Preclinical
Follow-up
up to 10 minutes
Authors
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Endothelial transport heterogeneity may explain atherosclerosis resistance; hypothesis-generating in rats and leaves open human relevance.
Differences in transendothelial macromolecular transport patterns between atherosclerosis-resistant and disease-prone vessels may explain the immunity of certain vessels to disease initiation.
Shou et al. (2007) studied Atherosclerosis. Horseradish peroxidase (HRP) introduction vs. Disease-prone vessels (aorta) was evaluated on Focal spot size growth and transendothelial transport patterns. Experimental introduction of horseradish peroxidase in rat vessels demonstrated focal spot growth differences between atherosclerosis-resistant and disease-prone vessels.
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