Population
Anesthetized New Zealand white rabbits fed a normal diet and after 3 weeks of lipid feeding. Atherosclerosis…
Comparison
Hypercholesterolemia and atherosclerosis vs Normal diet controls
Design
Preclinical
Follow-up
3 weeks
Authors
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Convection may dominate macromolecular transport in atherosclerotic arteries; leaves open implications for local delivery in clinical settings.
Convection plays a dominant role in the distribution of macromolecular agents following local delivery in atherosclerotic vessels, potentially resulting in rapid transport to the adventitia.
Baldwin et al. (1997) studied this question.
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