Key result
Drug diffusivities parallel to arterial connective tissue sheaths were 1-2 orders of magnitude greater than across them, with 66% greater transfer into the thoracic aorta than the carotid artery.
Why the study?
How does arterial ultrastructure influence the transport and distribution of locally delivered drugs?
How does arterial ultrastructure influence the transport and distribution of locally delivered drugs?
Arterial drug transport is highly anisotropic and dependent on local tissue composition and geometric organization, which is a critical consideration for optimizing local vascular drug delivery such as stent-based therapies.
No takes yet. Share an insight, caveat, or question.
Arterial drug transport anisotropy may affect local delivery by vessel; hypothesis-generating for ultrastructure-informed therapies.
Hwang et al. (2002) studied this question. Dextrans and albumin vs. Different geometric orientations and vascular beds was evaluated on Equilibrium drug uptake, penetration, and diffusivity. Drug diffusivities parallel to arterial connective tissue sheaths were 1-2 orders of magnitude greater than across them, with 66% greater transfer into the thoracic aorta than the carotid artery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: