Key result
Fluorescent albumin accumulates almost linearly over time in rabbit aortas by binding to medial elastin.
Population
Segments of rabbit aorta
Design
Preclinical
Follow-up
120 min
Authors
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Should not alter stent strategies yet; leaves open albumin-elastin affinity for targeted delivery in future studies.
Albumin binds to medial elastin layers in the aortic wall, suggesting it could serve as an affinity vehicle for stent-associated local drug delivery.
Goriely et al. (2007) studied this question. Fluorescently labeled albumin was evaluated on Diffusive transport and spatial distribution of albumin through artery walls. Fluorescently labeled albumin intensity increased almost linearly with time in rabbit aorta segments, reflecting gradual accumulation of albumin bound to medial elastin layers.
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