September 1, 1986Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

Uptake of low density lipoprotein, albumin, and water by deendothelialized in vitro minipig aorta.

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Population

Deendothelialized in vitro minipig aorta

Comparison

Application of pressure and flow over a 24-hour… vs Unpressurized tissue and nonstirred reagent

Design

Preclinical

Follow-up

24 hours

Authors

DFDonald L. FryGeneral / Preventive / Lipids JCJ. Fredrick CornhillUniversity of Oxford HSHari M. SharmaGovernment Medical College

Discussion

Member takes

Implication

Suggests hypertension may directly accelerate lipid accumulation following endothelial injury; leaves open whether.

Structured PICO

Population

Deendothelialized in vitro minipig aorta

Intervention

Application of pressure (100 mm Hg, 200 mm Hg) and flow (stirred reagent) over a 24-hour period

Comparator

Unpressurized tissue (0 mm Hg) and nonstirred reagent

Outcome

Arterial hydration (fractional mass of water) and in vitro transport of 125I-albumin and 125I-LDLsurrogate

In an in vitro model of deendothelialized minipig aorta, increased pressure significantly enhanced the uptake of albumin and LDL, particularly under nonstirred conditions.

Cite This Study

Fry et al. (1986) studied this question.

synapsesocial.com/papers/6a917af362841d9e29fb765f https://doi.org/10.1161/01.atv.6.5.475

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