December 1, 1987AJP Heart and Circulatory Physiology
Effect of pressure and intimal damage on 131I-albumin and 14Csucrose spaces in aorta
Population
Rabbit thoracic aorta in vitro
Comparison
Pressurization with air or liquid at 70 mmHg and… vs Relaxed arteries and intact vessels
Design
Preclinical
Authors
Discussion
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Implication
Animal data indicate pressure and endothelium modify arterial interstitial spaces; leaves open relevance to human vascular disease.
Structured PICO
P
Population
Rabbit thoracic aorta in vitro
I
Intervention
Pressurization with air or liquid at 70 mmHg and 180 mmHg, and removal of endothelium
C
Comparator
Relaxed arteries and intact vessels
O
Outcome
Distribution volume (space) for 131I-albumin and [14C]sucrose in the mediasurrogate
Interstitial volume and protein space within the arterial media can be modified by distending stresses and transmural fluid flux.
Cite This Study
Tedgui et al. (1987) studied this question.