Key result
Review highlights endothelial properties, transport, and autophagy as critical drivers of atherogenesis.
This review highlights the critical role of endothelial properties, transport mechanisms, and autophagy in the development of atherosclerosis.
Endothelial autophagy and transport merit mechanistic focus in atherosclerosis; leaves open whether targeting them improves outcomes.
This review discusses development of atherosclerosis as based on the evidence for its dependence on the properties of vessel endothelium. There is a detailed description of the mechanisms of atherogenesis, that were studied earlier, of the processes of endothelial transport, including caveola-dependent pathway and also the hemodynamic hypothesis of atherosclerosis development. The possibilities of the direct and receptor-mediated lipoprotein transcytosis through the endothelial barrier were discussed. A special attention was paid to the physiological function of autophagy responsible for the intracellular lipoprotein transport.
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Parfenova Ns (2020) conducted a review in Atherosclerosis. This review details the mechanisms of atherogenesis, emphasizing the dependence of atherosclerosis development on vessel endothelium properties, endothelial transport, and autophagy.
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