Why the study?
Does beta-adrenergic receptor stimulation induce a fetal gene program in neonate rat ventricular myocytes?
Does beta-adrenergic receptor stimulation induce a fetal gene program in neonate rat ventricular myocytes?
Beta1-adrenergic receptor stimulation induces a fetal gene program in neonatal rat ventricular myocytes via a cAMP-independent, CaMK-dependent pathway involving L-type Ca2+ channels.
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Does not support clinical changes in beta-blockade; leaves open human relevance of cAMP-independent CaMK pathways in remodeling.
Sucharov et al. (2006) studied this question.
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