Why the study?
Does endothelin receptor blockade prevent the reduction in thin-filament calcium sensitivity in failing Dahl salt-sensitive rat hearts?
Population
Dahl salt-sensitive rats fed a high-salt diet and age-matched low-salt controls
Comparison
Endothelin receptor blocker bosentan and in… vs Age-matched low-salt controls
Design
Preclinical
Authors
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Endothelin blockade preserved thin-filament calcium sensitivity in failing rat hearts; hypothesis-generating for human HF and requires clinical validation.
Does endothelin receptor blockade prevent the reduction in thin-filament calcium sensitivity in failing Dahl salt-sensitive rat hearts?
The transition to heart failure in Dahl salt-sensitive rats involves reduced thin-filament calcium sensitivity, which may be mediated by an endothelin-triggered pathway.
Noguchi et al. (2003) studied this question.
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