What question did this study set out to answer?

To develop a mild and cost-effective method for the direct C–H arylation of electron-deficient heterocycles using arylboronic acids.

September 2, 2010Journal of the American Chemical Society

Direct C−H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids

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Authors

ISIan B. SeipleScripps Research Institute SSShun SuBristol-Myers Squibb (Germany)RRRodrigo A. RodriguezUniversidad de La Frontera

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Implication

Experimental study demonstrates direct C–H arylation of electron-deficient heterocycles at room temperature, highlighting an inexpensive route for complex chemical synthesis.

Key Points

To develop a mild and cost-effective method for the direct C–H arylation of electron-deficient heterocycles using arylboronic acids.
Employed catalytic silver(I) nitrate in conjunction with a persulfate co-oxidant under ambient room-temperature conditions.
Evaluated substrate scope across diverse electron-deficient heterocycles and functionalized arylboronic acid coupling partners.
Enabled direct C–H arylation at room temperature utilizing accessible and inexpensive catalytic reagents.
Demonstrated broad functional group tolerance and substrate generality across various complex heterocycles that are challenging to functionalize via traditional routes.

Cite This Study

Seiple et al. (2010) studied this question.

synapsesocial.com/papers/6a100d91d13714ec96ff11d4 https://doi.org/10.1021/ja1066459

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Implication

Experimental study demonstrates direct C–H arylation of electron-deficient heterocycles at room temperature, highlighting an inexpensive route for complex chemical synthesis.

Direct C−H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids

Discussion

Member takes

Implication

Key Points

Cite This Study

Direct C−H Arylation of Electron-Deficient Heterocycles with Arylboronic Acids

Discussion

Member takes

Implication

Key Points

Cite This Study

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