Isosakuranetin ameliorates hypertension in rats induced by L-NAME

Figures

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  Fig. 1. Chemical structure of isosakuranetin

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  Fig. 2. Effect of isosakuranetin (ISO) on body weight (A) and heart rate (B) in rats with L-NAME-induced hypertension. Rats were treated with L-NAME to induce hypertension and subsequently administered ISO at doses of 10, 20, and 40 mg/kg. Enalapril 10 mg/kg was used as a positive control. Bars represent the mean ± SEM for each group. No statistically significant differences were observed among all groups

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  Fig. 3. Effect of isosakuranetin (ISO) on nitric oxide level. The alteration was demonstrated as plasma nitrite (NO2-) level which measured in the control group, control group treated with ISO 40 mg/kg, hypertension group (L-NAME treated group), and hypertension groups treated with ISO at 10, 20, or 40 mg/kg or enalapril at 10 mg/kg. Data are presented as mean ± SEM. *p < 0.05 vs. control group; #p < 0.05 and ##p < 0.01 vs. hypertension group

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  Fig. 4. Effect of isosakuranetin (ISO) on reactive oxygen species (ROS) production. The percentage of ROS levels compared to the control group was measured in different groups: control group treated with ISO 40 mg/kg, hypertension group (L-NAME treated group), and hypertension groups treated with ISO at 10, 20, or 40 mg/kg or enalapril at 10 mg/kg. Data are presented as mean ± SEM. Statistical significance is indicated as *p < 0.05 and **p < 0.01 compared to the control group

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  Fig. 5. Effect of isosakuranetin (ISO) on superoxide dismutase (SOD) activity. The level of SOD activity was measured in different groups: control group, control group treated with ISO 40 mg/kg , hypertension group (L-NAME treated group), and hypertension groups treated with ISO at 10, 20, or 40 mg/kg or enalapril at 10 mg/kg. Data are presented as mean ± SEM. Statistical significance is indicated as **p < 0.01 and ***p < 0.001 vs. control group; #p < 0.05 and ###p < 0.001 vs. hypertension group