August 1, 1995Circulation

Vascular Cell Adhesion Molecule–1 Is Induced on Vascular Endothelia and Medial Smooth Muscle Cells in Experimental Cardiac Allograft Vasculopathy

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Population

Murine model of cardiac allograft vasculopathy

Design

Preclinical

Follow-up

1 to 2 months

Authors

AAA. ArdehaliUniversity of British Columbia HLHillel LaksCardiac Surgery DDDavis C. DrinkwaterCentennial Medical Center

Discussion

Member takes

Implication

Supports local immune mediation in cardiac allograft vasculopathy models; leaves open translation to human transplant vasculopathy.

Structured PICO

Population

Murine model of cardiac allograft vasculopathy (B10.A strain hearts transplanted heterotopically into B10.BR strain recipients)

Intervention

Heterotopic heart transplantation to induce experimental cardiac allograft vasculopathy

Outcome

Expression of cellular infiltrate, MHC antigens, ICAM-1, and VCAM-1 in vascular lesions assessed by immunohistochemistrysurrogate

Experimental cardiac allograft vasculopathy is a local immune-mediated process where endothelial and medial smooth muscle cells express VCAM-1 and unmatched MHC antigens, acting as immune targets and stimulators.

Cite This Study

Ardehali et al. (1995) studied this question.

synapsesocial.com/papers/6a1017eb8090e499da609b69 https://doi.org/10.1161/01.cir.92.3.450

Topics

Heart transplantation

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Vascular Cell Adhesion Molecule–1 Is Induced on Vascular Endothelia and Medial Smooth Muscle Cells in Experimental Cardiac Allograft Vasculopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Vascular Cell Adhesion Molecule–1 Is Induced on Vascular Endothelia and Medial Smooth Muscle Cells in Experimental Cardiac Allograft Vasculopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider