October 1, 1999Journal of Applied Physiology
Muscle interstitial glucose and lactate levels during dynamic exercise in humans determined by microdialysis
Why the study?
Does dynamic incremental exercise alter skeletal muscle interstitial glucose and lactate concentrations in humans?
Population
Humans
Comparison
Dynamic incremental knee extensor exercise at… vs Rest
Authors
Discussion
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Member takes
Implication
Interstitial glucose-lactate gradients persist during exercise; leaves open effects on muscle metabolism and needs prospective validation before clinical consideration.
Structured PICO
Does dynamic incremental exercise alter skeletal muscle interstitial glucose and lactate concentrations in humans?
P
Population
Humans
I
Intervention
Dynamic incremental knee extensor exercise at workloads of 10, 20, 30, 40, and 50 W with microdialysis probes inserted into the vastus lateralis muscle
C
Comparator
Rest
O
Outcome
Skeletal muscle interstitial glucose and lactate concentrationssurrogate
Interstitial glucose delivery at rest is flow-limited, and skeletal muscle contraction increases the diffusion coefficient of glucose and lactate within the interstitial space.
Cite This Study
MacLean et al. (1999) studied this question.