Key result
Moderate sodium restriction significantly lowered supine blood pressure to 138/88 mm Hg compared to 147/91 mm Hg with sodium supplementation in patients on captopril and hydrochlorothiazide (p<0.05).
Why the study?
Does moderate sodium restriction reduce blood pressure in hypertensive patients already treated with a converting enzyme inhibitor and a thiazide diuretic?
Population
21 patients with essential hypertension already being treated with the combination of a converting enzyme…
Comparison
Moderate sodium restriction plus Slow Sodium… vs Moderate sodium restriction plus Slow Sodium…
Design
RCT, randomized, crossover, double-blind
Follow-up
1 month per crossover period
Authors
Loading...
Moderate sodium restriction augments BP control on ACEI plus thiazide; extends RCT evidence for combined lifestyle-pharmacologic hypertension management.
RCT (n=21)
Double-blind
crossover
Does moderate sodium restriction reduce blood pressure in hypertensive patients already treated with a converting enzyme inhibitor and a thiazide diuretic?
p-value: p=<0.05
Moderate sodium restriction provides an additive blood pressure-lowering effect in hypertensive patients already treated with a combination of an ACE inhibitor and a thiazide diuretic.
Singer et al. (1991) conducted an RCT in essential hypertension (n=21). Moderate sodium restriction (Slow Sodium placebo) vs. Slow Sodium tablets (100 mmol sodium/day) was evaluated on supine blood pressure 2 hours after treatment (p=<0.05). Moderate sodium restriction significantly lowered supine blood pressure to 138/88 mm Hg compared to 147/91 mm Hg with sodium supplementation in patients on captopril and hydrochlorothiazide (p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: