What question did this study set out to answer?

To determine whether moderate dietary salt restriction causes an additional decrease in blood pressure among treated hypertensive men who concurrently reduce alcohol consumption.

October 1, 1990Hypertension

Two-way factorial study of alcohol and salt restriction in treated hypertensive men.

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Hypertension (n=63). Intervention: Alcohol and salt restriction vs. Usual alcohol intake and normal sodium intake. Primary outcome: Change in supine systolic blood pressure (p=<0.01).

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Key result

Reducing alcohol intake in treated hypertensive men significantly lowered supine systolic (-5.4 mm Hg, p<0.01) and diastolic (-3.2 mm Hg, p<0.01) blood pressure.

Why the study?

Does moderate restriction of dietary salt and alcohol intake reduce blood pressure in treated hypertensive men?

Population

63 treated hypertensive men

Comparison

Two-way factorial design: alcohol restriction… vs Usual alcohol intake and/or normal sodium intake

Design

RCT, randomly assigned, placebo-controlled for the sodium arm

Follow-up

4 weeks

Authors

MPMegan N. ParkerUniformed Services University of the Health Sciences IPIan B. PuddeyGeneral / Preventive / Lipids LBLawrence J. BeilinGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Reducing alcohol intake lowers BP in treated hypertensive men; confirms benefit of lifestyle intervention alongside pharmacotherapy.

Key Points

To determine whether moderate dietary salt restriction causes an additional decrease in blood pressure among treated hypertensive men who concurrently reduce alcohol consumption.
Enrolled 63 treated hypertensive men into a 2-week familiarization phase on a low-sodium diet (<60 mmol/day) supplemented with 100 mmol/day sodium chloride tablets while continuing normal alcohol intake.
Randomly allocated participants in a 4-week factorial design to either low alcohol (low-alcohol beer; self-reported intake 537 to 57 ml/week) or normal alcohol (543 vs. 557 ml/week), combined with low sodium (placebo tablets) or normal sodium (100 mmol/day sodium chloride tablets).
Continued standard antihypertensive drug therapy throughout the trial, with 59 subjects completing the intervention.
Alcohol restriction produced a significant reduction in supine systolic blood pressure of -5.4 mm Hg (p < 0.01) and supine diastolic blood pressure of -3.2 mm Hg (p < 0.01).
Sodium restriction reduced 24-hour urinary sodium excretion from 144 to 69 mmol/day in the low-sodium group, while excretion remained stable in the normal-sodium group (125 vs. 142 mmol/day).

Study Design

Type

RCT (n=63)

Blinding

Placebo-controlled

Randomization

Factorial

Structured PICO

Does moderate restriction of dietary salt and alcohol intake reduce blood pressure in treated hypertensive men?

Population

63 treated hypertensive men

Intervention

Two-way factorial design: alcohol restriction (low alcohol beer) and/or dietary salt restriction (low sodium diet + placebo tablets) for 4 weeks

Comparator

Usual alcohol intake and/or normal sodium intake (low sodium diet + 100 mmol/day sodium chloride tablets)

Outcome

Change in systolic and diastolic blood pressuresurrogate

Main Result

p-value: p=<0.01

Reducing alcohol intake significantly lowers both systolic and diastolic blood pressure in treated hypertensive men.

Cite This Study

Parker et al. (1990) conducted an RCT in Hypertension (n=63). Alcohol and salt restriction vs. Usual alcohol intake and normal sodium intake was evaluated on Change in supine systolic blood pressure (p=<0.01). Reducing alcohol intake in treated hypertensive men significantly lowered supine systolic (-5.4 mm Hg, p<0.01) and diastolic (-3.2 mm Hg, p<0.01) blood pressure.

synapsesocial.com/papers/6a1028e4d13714ec96ff48ee https://doi.org/10.1161/01.hyp.16.4.398

Topics

Hypertension management

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Two-way factorial study of alcohol and salt restriction in treated hypertensive men.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Two-way factorial study of alcohol and salt restriction in treated hypertensive men.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider