Key result
Patients with NIDDM showed a significantly reduced ability of insulin to suppress plasma free fatty acid concentrations and stimulate glucose uptake compared to normal subjects (P<0.001).
Why the study?
Is the ability of insulin to suppress plasma free fatty acid concentrations and stimulate glucose uptake reduced in patients with noninsulin-dependent diabetes mellitus compared to normal subjects?
Population
24 subjects: 12 individuals with normal glucose tolerance and 12 patients with noninsulin-dependent diabetes…
Comparison
5-hour glucose clamp studies, carried out at… vs Individuals with normal glucose tolerance.
Design
Cross-sectional
Follow-up
5 hours
Authors
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Impaired insulin action on glucose uptake and FFA suppression in NIDDM supports systemic resistance; leaves open causal mechanisms and therapeutic relevance.
Cross-Sectional (n=24)
Is the ability of insulin to suppress plasma free fatty acid concentrations and stimulate glucose uptake reduced in patients with noninsulin-dependent diabetes mellitus compared to normal subjects?
p-value: p=<0.001
Patients with NIDDM exhibit significant resistance to insulin's ability to suppress plasma free fatty acid levels and stimulate tissue glucose uptake.
CHEN et al. (1987) conducted a cross-sectional in Noninsulin-dependent diabetes mellitus (NIDDM) (n=24). Insulin (glucose clamp) vs. Normal glucose tolerance subjects was evaluated on Ability of insulin to stimulate tissue glucose uptake and lower plasma FFA concentrations (p=<0.001). Patients with NIDDM showed a significantly reduced ability of insulin to suppress plasma free fatty acid concentrations and stimulate glucose uptake compared to normal subjects (P<0.001).
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