What question did this study set out to answer?

To determine whether hepatic and extrahepatic insulin resistance are equally severe and whether glucose effectiveness is impaired under physiological postprandial conditions in non-insulin-dependent diabetes mellitus.

December 1, 1994Journal of Clinical InvestigationOpen Access

Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans.

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Authors

AAAus AlzaidKing Khaled Hospital SDSeán F. DinneenUniversity Hospital Galway DTD. TurkMayo Clinic

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Implication

Metabolic clamp study demonstrates severe peripheral resistance with intact glucose self-regulation in type 2 diabetes, indicating preserved non-insulin-mediated uptake.

Key Points

To determine whether hepatic and extrahepatic insulin resistance are equally severe and whether glucose effectiveness is impaired under physiological postprandial conditions in non-insulin-dependent diabetes mellitus.
Assessed diabetic and nondiabetic subjects across euglycemic (5 mM) clamps and postprandial-like hyperglycemic conditions.
Infused insulin to recreate a physiological, nondiabetic post-meal concentration curve across both groups.
Under euglycemia, insulin stimulated glucose disposal in nondiabetic controls but not in diabetic subjects, while suppression of endogenous glucose release was only mildly blunted in diabetes (-1.06 ± 0.09 vs. -1.47 ± 0.21 nmol·kg⁻¹ per 4 h, P < 0.05).
Glucose effectiveness did not differ significantly between diabetic and nondiabetic subjects for enhancement of disposal (0.59 ± 0.18 vs. 0.62 ± 0.17 nmol·kg⁻¹ per 4 h) or suppression of release (-0.36 ± 0.12 vs. -0.14 ± 0.12 nmol·kg⁻¹ per 4 h).

Cite This Study

Alzaid et al. (1994) studied this question.

synapsesocial.com/papers/6a11d8d83f4fe1a84cb4cbb3 https://doi.org/10.1172/jci117599

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Implication

Metabolic clamp study demonstrates severe peripheral resistance with intact glucose self-regulation in type 2 diabetes, indicating preserved non-insulin-mediated uptake.

Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans.

Discussion

Member takes

Implication

Key Points

Cite This Study

Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans.

Discussion

Member takes

Implication

Key Points

Cite This Study

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