Comparison of Different Measures of Urinary Protein Excretion for Prediction of Renal Events
Why the study?
Does the albumin:creatinine ratio (ACR) from a first-morning void better predict renal events compared to other measures of urinary protein excretion in patients with type 2 diabetes and nephropathy?
Population
n=701 patients with type 2 diabetes and nephropathy (subset of the RENAAL trial)
Comparison
Measurement of urinary albumin:creatinine ratio… vs Other measures of urinary protein excretion…
Design
Cohort
Authors
Discussion
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Member takes
Implication
Supports first-morning ACR for renal risk prediction in type 2 diabetes; leaves open whether it should replace other measures in practice.
Structured PICO
Does the albumin:creatinine ratio (ACR) from a first-morning void better predict renal events compared to other measures of urinary protein excretion in patients with type 2 diabetes and nephropathy?
P
Population
n=701 patients with type 2 diabetes and nephropathy (subset of the RENAAL trial)
I
Intervention
Measurement of urinary albumin:creatinine ratio (ACR) from a first-morning void
C
Comparator
Other measures of urinary protein excretion: urinary protein excretion (UPE) and urinary albumin excretion (UAE) from a 24-hour urine collection, and urinary albumin concentration (UAC) from a first-morning void
O
Outcome
Time to a doubling of serum creatinine or end-stage renal diseasehard clinical
Measurement of the albumin:creatinine ratio in a first-morning void is superior to 24-hour urine collections for predicting renal events in patients with type 2 diabetes and nephropathy.
Cite This Study
Heerspink et al. (2010) studied this question.