Why the study?
Does berberine inhibit EV71 replication in infected Vero cells?
Population
African green monkey kidney (Vero) cells infected with Enterovirus 71 (EV71) strains (SHZH98, BrCr, H, JS-52)
Comparison
Berberine (BBR) at various concentrations vs Mock-infected cells, untreated EV71-infected…
Design
Preclinical
Authors
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Hypothesis-generating for berberine in EV71; leaves open clinical translation.
Does berberine inhibit EV71 replication in infected Vero cells?
Berberine demonstrates in vitro antiviral activity against Enterovirus 71 by downregulating the MEK/ERK signaling pathway and autophagy.
Wang et al. (2017) studied this question.
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