Why the study?
Does blocking autophagy reduce viral replication and pathogenesis in EV71-infected suckling mice?
Population
Human neuroblastoma (SK-N-SH) cells, human rhabdomyosarcoma (RD) cells, and 7-day-old ICR suckling mice
Comparison
Infection with Enterovirus 71 and treatment with… vs Uninfected controls and EV71-infected controls…
Design
Preclinical
Follow-up
up to 10 days
Authors
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Autophagy inhibition attenuates EV71 in mice; leaves open translation to clinical use.
Does blocking autophagy reduce viral replication and pathogenesis in EV71-infected suckling mice?
EV71 infection induces autophagy which promotes viral replication and pathogenesis in a suckling mouse model, suggesting autophagy inhibitors could be a potential therapeutic target.
Lee et al. (2014) studied this question.
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