Why the study?
EV-A71 VP1 induces autophagy to facilitate replication, but the underlying mechanism remained unclear.
The interaction between host protein PHB2 and EV-A71 VP1 is essential for inducing autophagy and promoting viral infection.
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EV-A71 VP1 may exploit autophagy for replication in HFMD; leaves open whether targeting this pathway alters pediatric outcomes.
Su et al. (2020) studied this question.
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