March 20, 2015VirusesOpen Access

Both ERK1 and ERK2 Are Required for Enterovirus 71 (EV71) Efficient Replication

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Population

In vitro model of Enterovirus 71 (EV71) infection

Design

Preclinical

Authors

Discussion

Both ERK isoforms are non-redundant for EV71 replication; hypothesis-generating for host-directed antivirals.

Population

In vitro model of Enterovirus 71 (EV71) infection

Intervention

Specific ERK siRNAs and selective inhibitor U0126

Outcome

EV71 propagation, viral RNA amplification, and protein synthesissurrogate

Both ERK1 and ERK2 are critical and non-interchangeable for efficient EV71 replication, particularly during the late phase of activation.

Zhu et al. (2015) studied this question.

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