Myocardial beta adrenoceptor density in primary and secondary left ventricular hypertrophy
Key result
Myocardial beta-adrenoceptor density was reduced in hypertrophic cardiomyopathy (7.70 vs 10.17 pmol/g, P<0.01) and secondary left ventricular hypertrophy (6.35 vs 9.16 pmol/g, P<0.01) vs controls.
Why the study?
Is myocardial beta-adrenoceptor density decreased in both primary and secondary left ventricular hypertrophy compared to normal controls?
Population
37 subjects total: 11 patients with hypertrophic cardiomyopathy, 8 patients with left ventricular…
Design
Cross-sectional
Authors
Discussion
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Implication
May indicate shared beta-adrenergic remodeling in primary and secondary LVH; leaves open its role in disease progression.
Study Design
Type
Case-Control (n=37)
Structured PICO
Is myocardial beta-adrenoceptor density decreased in both primary and secondary left ventricular hypertrophy compared to normal controls?
P
Population
37 subjects total: 11 patients with hypertrophic cardiomyopathy (mean age 37), 8 patients with left ventricular hypertrophy secondary to arterial hypertension or aortic valve disease (mean age 64), and 18 normal control subjects (mean age 50).
C
Comparator
Normal control subjects
O
Outcome
Myocardial beta-adrenoceptor density measured by positron emission tomography with 11C-CGP-12177surrogate
Main Result
p-value: p=<0.01
Myocardial beta-adrenoceptor density is comparably decreased in both primary (hypertrophic cardiomyopathy) and secondary left ventricular hypertrophy despite preserved systolic function.
Cite This Study
Choudhury et al. (1996) conducted a case-control in Primary and secondary left ventricular hypertrophy (n=37). Positron emission tomography with 11C-CGP-12177 vs. Normal control subjects was evaluated on Myocardial beta-adrenoceptor density (p=<0.01). Myocardial beta-adrenoceptor density was reduced in hypertrophic cardiomyopathy (7.70 vs 10.17 pmol/g, P<0.01) and secondary left ventricular hypertrophy (6.35 vs 9.16 pmol/g, P<0.01) vs controls.