Key result
Intercompartmental clearance of thiopental decreased by 35% between ages 20 and 80 years, whereas the central blood pool volume did not decrease with increasing age.
Why the study?
How does age affect the pharmacokinetics of early drug distribution of thiopental?
Population
21 patients, aged 20-80 yr
Design
Other
Authors
Loading...
Challenges assumptions of reduced central volume with age for thiopental; leaves open whether clearance decline warrants adjusted dosing in elderly.
Observational (n=21)
How does age affect the pharmacokinetics of early drug distribution of thiopental?
Age-related changes in thiopental pharmacokinetics are driven by a 35% decrease in intercompartmental clearance rather than a decrease in central volume, suggesting dose adjustments should not be made on the basis of age alone.
Avram et al. (1990) conducted an observational in Pharmacokinetics of early drug distribution (n=21). Thiopental and indocyanine green was evaluated on Pharmacokinetic variables (V1 and Cl21). Intercompartmental clearance of thiopental decreased by 35% between ages 20 and 80 years, whereas the central blood pool volume did not decrease with increasing age.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: