Effect of Hydro-Alcoholic Poly Herbal Formulation on Cardiac Markers With Atherogenic Diet Fed Animal Model of Obesity in Wistar Rats

Aim: Pharmacological screening of obesity were planned in response to an atherogenic diet and to estimate the effect of Cyperus Rotundus Linn, Terminalia Arjuna & Cinnamomum Zeylanicum Nees, on plasma Adiponectin, cardiac function markers, ECG and heart rate in wistar rats. Obesity associated with Cardio vascular properties is rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can modulate obesity. Obesity was induced by feed with an atherogenic diet for over a period of 60 days. Methods: The hydro-alcoholic extract of herbal formulation containing Cyperous rotundus, Terminalia arjuna and Cinnamomum zeylanicum was administered orally in dose of 480mg/kg, p.o (high dose), 360mg/kg p.o (mid dose) and 120mg/kg p.o (low dose) was administered, daily body weight, locomotor activity, organ and fat pad weights, plasma adiponectin, renal function and cardiac markers were analyzed.Results: Atherogenic diet induced obesity associated with an altered cardiac biomarkers, Plasma Adiponectin and cardiac parameters (ECG, Heart rate); this may have implications for the progress of obesity related problems and it significantly increased final body weight, fat pad weights, triglycerides (TG), total cholesterol HDL, & LDL concentration, moreover treatment with Cyperus rotundus poly herbal formulation extract improved obesity and its associated metabolic problems at different levels. Conclusion: Cyperus rotundus linn might be a safe drug on the target organs with no pathological impact since it lowed that extant damage of an Atherogenic diet induced obesity and exhibited a distinct anti-obesity effect.