Population
Guinea pig isolated hearts, left atrial tissue, and ventricular/atrial membrane preparations
Design
Preclinical
Authors
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Species differences in myocardial Ang II signaling warrant caution extrapolating rodent data; leaves open human receptor-effector coupling.
Guinea pig myocardium contains angiotensin II receptors coupled to inositol phosphate production, even though it lacks the inotropic response seen in other mammals.
Baker et al. (1988) studied this question.
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