Why the study?
Does the slope of the pressure-volume relationship during afterload stress correlate with left ventricular functional response to exercise in asymptomatic patients with aortic regurgitation?
Population
14 asymptomatic patients with isolated moderate-to-severe aortic regurgitation and 6 control subjects
Comparison
Radionuclide ventriculography during angiotensin… vs Control subjects
Design
Cross-sectional
Authors
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Lower pressure-volume slope indicates LV dysfunction in aortic regurgitation; supports evaluation as a marker of subclinical dysfunction but should not yet change practice.
Does the slope of the pressure-volume relationship during afterload stress correlate with left ventricular functional response to exercise in asymptomatic patients with aortic regurgitation?
In asymptomatic patients with aortic regurgitation, resting ejection fraction may overestimate myocardial function, whereas the pressure-volume relationship during afterload stress and LVEF response to exercise more reliably reflect LV dysfunction.
Shen et al. (1985) studied this question.
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