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May 1, 1963Journal of Applied Physiology

Effects of continuous administration of angiotensin II on ventricular performance

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Key result

Continuous administration of angiotensin II in cats produced transient changes in ventricular contractility and occasional prolonged myocardial depression, unlike the sustained increase with norepinephrine.

Authors

SDS. E. DowningDuquesne UniversityESEdmund H. SonnenblickUniversity of Parma

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Implication

Potential myocardial depression risk with sustained angiotensin II warrants monitoring; leaves open human vasopressor implications.

Key Points

  • The aim is to evaluate how continuous angiotensin II administration affects heart function and circulatory dynamics.
  • Studied effects in cats with equal doses of angiotensin II and norepinephrine.
  • Measured blood pressure, ventricular contractility, and coronary blood flow.
  • Highlighted acute and prolonged effects of continuous infusion.
  • Continuous angiotensin II led to initial blood pressure rise, then a rapid return to intermediate values.
  • Marked acute myocardial depression was observed in one-third of subjects with prolonged angiotensin II infusion.
  • Contrast with norepinephrine infusion, which consistently showed an increase in coronary blood flow and contractility.

PICO

P
Population
Circulatory dynamics and coronary blood flow
I
Intervention / Comparator
Angiotensin II vs Norepinephrine (Continuous administration)
O
Primary Outcome
Circulatory dynamics, ventricular contractility, and coronary blood flow

Cite This Study

Downing et al. (1963) studied Circulatory dynamics and coronary blood flow. Angiotensin II vs. Norepinephrine was evaluated on Circulatory dynamics, ventricular contractility, and coronary blood flow. Continuous administration of angiotensin II in cats produced transient changes in ventricular contractility and occasional prolonged myocardial depression, unlike the sustained increase with norepinephrine.

synapsesocial.com/papers/6a1069412badbc352afff674https://doi.org/10.1152/jappl.1963.18.3.585
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of angiotensin II on myocardial contractility during short-term pressor responses to angiotensin II1997 · 5 citations
  2. 2Acute effects of angiotensin II on myocardial performance2001 · 6 citations
  3. 3Coronary and Myocardial Actions of Angiotensin1964 · 100 citations
  4. 4Effects of Synthetic Angiotensin II on Catecholamine Levels and Biological Activity1965 · 16 citations
  5. 5The Cardiac Effects of Intracoronary Angiotensin II Infusion2002 · 7 citations