April 1, 1963Circulation ResearchOpen Access

Cardiovascular Effects of Infusions of Epinephrine and Angiotensin Singly and in Combination

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Population

Anesthetized dogs

Design

Preclinical

Follow-up

30 minutes

Authors

PBP. F. BinnionPennsylvania Hospital JHJ. D. HatcherInnovative Genomics Institute

Discussion

Member takes

Implication

No immediate change to clinical vasopressor use; leaves open translation of epinephrine-angiotensin synergy to humans.

Structured PICO

Population

Anesthetized dogs

Intervention

Infusions of epinephrine (0.1 and 0.2 mcg/kg per min) and angiotensin (0.05 mcg/kg per min) singly and in combination for 30 minutes

Outcome

Cardiovascular hemodynamics including cardiac output, arterial blood pressure, total peripheral resistance, right ventricular pressure, and left ventricular stroke worksurrogate

In a canine model, the combination of epinephrine and angiotensin transiently augments cardiac output and stroke work, highlighting potential synergistic hemodynamic effects during acute stress.

Cite This Study

Binnion et al. (1963) studied this question.

synapsesocial.com/papers/6a1069412badbc352afff675 https://doi.org/10.1161/01.res.12.4.393

Topics

Hypertension management

View Full Paper

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Bookmark

Cardiovascular Effects of Infusions of Epinephrine and Angiotensin Singly and in Combination

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cardiovascular Effects of Infusions of Epinephrine and Angiotensin Singly and in Combination

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider