Protective Roles of Mast Cells and Mast Cell-Derived TNF in Murine Malaria
Why the study?
Do mast cells and mast cell-derived TNF play a protective role in murine malaria?
Population
Mast cell-deficient WBB6F1-W/W (W/W) and control littermate WBB6F1+/+ mice infected with 1 x 10 of…
Comparison
Reconstitution with bone marrow-derived mast… vs W/W(v) mice without reconstitution or +/+ mice
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Mast cell TNF may protect against experimental malaria; leaves open human relevance and therapeutic targeting.
Structured PICO
Do mast cells and mast cell-derived TNF play a protective role in murine malaria?
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Population
Mast cell-deficient WBB6F1-W/W(v) (W/W(v)) and control littermate WBB6F1+/+ (+/+) mice infected with 1 x 10(5) of Plasmodium berghei ANKA
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Intervention
Reconstitution with bone marrow-derived mast cells (BMMCs) of +/+ mice or TNF-/- mice; activation of mast cells by anti-IgE or compound 48/80
C
Comparator
W/W(v) mice without reconstitution or +/+ mice
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Outcome
Parasitemia and mortalitysurrogate
Mast cells and mast cell-derived TNF play protective roles against murine malaria by reducing parasitemia and mortality.
Cite This Study
Furuta et al. (2006) studied this question.