Modeling the His-Purkinje Effect in Non-invasive Estimation of Endocardial and Epicardial Ventricular Activation

4 subjects referred for a clinical endocardial and epicardial electro-anatomical mapping (EAM) procedure. Includes 1 subject with symptomatic premature ventricular contractions originating in the right ventricular outflow tract without structural heart disease, and 3 subjects with recurrent ventricular tachycardias with underlying arrhythmogenic cardiomyopathy or dilated cardiomyopathy.

Multi-wave inverse electrocardiography (iECG) method, which models the effect of the His-Purkinje system on ventricular activation using 67-electrode body surface potential maps (BSPM).

Multi-focal iECG method, which does not take the effect of the His-Purkinje system into account.

Correlation coefficient (CC) and mean absolute difference in local activation timing (LAT) between estimated iECG maps and invasive LAT maps.surrogate