Adherence to a Low-Risk, Healthy Lifestyle and Risk of Sudden Cardiac Death Among Women
Key result
Adherence to 4 low-risk lifestyle factors was associated with a significantly lower risk of sudden cardiac death compared to 0 low-risk factors (RR 0.08; 95% CI 0.03-0.23).
Why the study?
Does adherence to a low-risk lifestyle reduce the risk of sudden cardiac death in women?
Population
81,722 US women in the Nurses' Health Study
Comparison
Adherence to a low-risk lifestyle vs Women with 0 low-risk lifestyle factors
Design
Cohort
Follow-up
26 years
Authors
Discussion
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Member takes
Implication
Supports lifestyle counseling for SCD prevention in women; hypothesis-generating and requires RCTs before practice change.
Key Points
- To estimate how adherence to a healthy lifestyle reduces the risk of sudden cardiac death among women.
- Prospective cohort study of 81,722 US women in the Nurses' Health Study
- Assessment of lifestyle factors via questionnaires every 2 to 4 years
- Follow-up duration from June 1984 to June 2010.
- 321 cases of sudden cardiac death identified over 26 years of follow-up
- Multivariable relative risk of SCD was 0.54 for 1 low-risk factor, 0.41 for 2, 0.33 for 3, and 0.08 for 4 low-risk factors
- 81% of SCD cases were attributable to smoking, inactivity, overweight, and poor diet.
Study Design
Type
Cohort (n=81,722)
Structured PICO
Does adherence to a low-risk lifestyle reduce the risk of sudden cardiac death in women?
P
Population
81,722 US women in the Nurses' Health Study
I
Intervention
Adherence to a low-risk lifestyle (not smoking, body mass index of less than 25, exercise duration of 30 minutes/day or longer, and top 40% of the alternate Mediterranean diet score)
C
Comparator
Women with 0 low-risk lifestyle factors
O
Outcome
Sudden cardiac death (defined as death occurring within 1 hour after symptom onset without evidence of circulatory collapse)hard clinical
Main Result
Effect estimate: RR 0.08 (95% CI 0.03-0.23)
Absolute Event Rate: 16% vs 22%
Adherence to a low-risk lifestyle consisting of no smoking, normal BMI, regular exercise, and a Mediterranean diet is associated with a substantially lower risk of sudden cardiac death among women.
Cite This Study
Chiuve et al. (2011) conducted a cohort in Sudden cardiac death (n=81,722). Low-risk lifestyle (not smoking, BMI <25, exercise ≥30 min/day, top 40% Mediterranean diet) vs. 0 low-risk lifestyle factors was evaluated on Sudden cardiac death (RR 0.08, 95% CI 0.03-0.23). Adherence to 4 low-risk lifestyle factors was associated with a significantly lower risk of sudden cardiac death compared to 0 low-risk factors (RR 0.08; 95% CI 0.03-0.23).