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May 15, 1997Annals of Internal Medicine

Clarifying the Direct Relation between Total Cholesterol Levels and Death from Coronary Heart Disease in Older Persons

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Why the study?

Does elevated total cholesterol level increase the risk of death from coronary heart disease in older adults when adjusting for co-occurring diseases and frailty?

Population

4066 older men and women from East Boston, Massachusetts; Iowa and Washington counties, Iowa; and New Haven…

Comparison

Elevated total cholesterol levels vs Lowest total cholesterol levels

Design

Cohort

Follow-up

5 years

Authors

MCMaria Chiara CortiZero Emissions Resource OrganisationJGJack M. GuralnikUniversity of Maryland, BaltimoreMSMarcel E. SaliveNational Institutes of Health

Discussion

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Implication

Elevated cholesterol predicts CHD mortality in older adults after frailty adjustment; leaves open whether lowering levels improves outcomes in this population.

Structured PICO

Does elevated total cholesterol level increase the risk of death from coronary heart disease in older adults when adjusting for co-occurring diseases and frailty?

P
Population
4066 older men and women from East Boston, Massachusetts; Iowa and Washington counties, Iowa; and New Haven, Connecticut
I
Intervention
Elevated total cholesterol levels (≥ 6.20 mmol/L [≥ 240 mg/dL])
C
Comparator
Lowest total cholesterol levels (≤ 4.15 mmol/L [≤ 160 mg/dL])
O
Outcome
Death from coronary heart diseasehard clinical

Elevated total cholesterol is a risk factor for CHD death in older adults, and the apparent paradox of low cholesterol being associated with higher mortality is secondary to comorbidity and frailty.

Cite This Study

Corti et al. (1997) studied this question.

synapsesocial.com/papers/6a10752ae1a472cb5efcf13ehttps://doi.org/10.7326/0003-4819-126-10-199705150-00001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between total cholesterol and all-cause mortality in oldest old: a national longitudinal study2024 · 6 citations
  2. 2Serum total cholesterol levels and all-cause mortality in a home-dwelling elderly population: a six-year follow-up2010 · 61 citations
  3. 3Total and High Density Lipoprotein Cholesterol as Risk Factors for Coronary Heart Disease in Elderly Men during 5 Years of Follow-up: The Zutphen Elderly Study1996 · 47 citations
  4. 4Serum Cholesterol and Impact of Age on Coronary Heart Disease Death in More Than 4 Million Veterans2023 · 16 citations
  5. 5Long‐Term Prognostic Importance of Total Cholesterol in Elderly Survivors of an Acute Myocardial Infarction: The Cooperative Cardiovascular Pilot Project2003 · 17 citations