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June 13, 2024Frontiers in EndocrinologyOpen Access

Association between total cholesterol and all-cause mortality in oldest old: a national longitudinal study

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Authors

FHFan HuFirst Affiliated Hospital of Jiangxi Medical CollegeZWZhiqiang WangHenry Ford Health SystemYLYujie LiuHarbin Medical University

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Implication

Longitudinal study shows lower all-cause mortality in oldest old with higher cholesterol levels, suggesting health implications.

Key Points

  • All-cause mortality was inversely associated with total cholesterol levels in participants aged 85 and older, indicating a surprising health relationship.
  • The hazard ratio for total cholesterol levels between 3.40–4.39 mmol/L was 0.72, and for levels ≥4.39 mmol/L was 0.71, demonstrating lower mortality compared to <3.40 mmol/L.
  • The analysis included 903 participants, followed from 2012 to 2014, using Cox regression and Kaplan-Meier methods for survival assessment and comparison between groups with different cholesterol levels.  The outcomes highlight the necessity of maintaining total cholesterol levels above 3.40 mmol/L for longevity in this age group.

Cite This Study

Hu et al. (2024) studied this question.

synapsesocial.com/papers/68e64e8bb6db6435875df142https://doi.org/10.3389/fendo.2024.1405283
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Mortality in Older Persons with Hypocholesterolemia: Cause or Effect1995 · 7 citations
  2. 2Ranking age-specific modifiable risk factors for cardiovascular disease and mortality: evidence from a population-based longitudinal study2023 · 109 citations
  3. 3MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS1996 · 10,022 citations
  4. 4Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality2019 · 335 citations
  5. 5Epidemiology of low cholesterol levels in older adults. The Cardiovascular Health Study.1993 · 66 citations