What question did this study set out to answer?

To examine the association between serum total cholesterol levels and 10-year all-cause mortality in a very elderly, community-dwelling population.

February 1, 2014Clinical Interventions in AgingOpen Access

Serum total cholesterol concentration and 10-year mortality in an 85-year-old population

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Why the study?

Does lower serum total cholesterol concentration increase all-cause mortality in a very elderly (85-year-old) population?

Population

207 community-dwelling very elderly participants (85 years old)

Comparison

High total cholesterol or intermediate total… vs Low total cholesterol (≤175 mg/dL)

Design

Cohort

Follow-up

10 years

Authors

YTYutaka TakataKyushu Dental University TAToshihiro AnsaiKyushu Dental University ISInho SohKyushu Dental University

Discussion

Member takes

Implication

Lower TC/LDL-C associated with higher mortality in very elderly; hypothesis-generating and should not change practice.

Key Points

To examine the association between serum total cholesterol levels and 10-year all-cause mortality in a very elderly, community-dwelling population.
Followed 207 participants aged 85 years over 10 years (2003–2013), tracking survival outcomes alongside baseline blood metrics, blood pressure, BMI, and lifestyle surveys.
Categorized baseline total cholesterol (TC) into high (≥209 mg/dL), intermediate (176–208 mg/dL), and low (≤175 mg/dL) groups.
Evaluated survival using the Kaplan-Meier method and multivariate Cox proportional hazards regression adjusted for sex, smoking, alcohol use, stroke or heart disease history, serum albumin, BMI, and systolic blood pressure.
Kaplan-Meier survival curves indicated that participants in both the high-TC and intermediate-TC groups survived longer than those in the low-TC group, with survival benefits driven primarily by men.
Multivariate Cox regression showed that all-cause mortality in the low-TC group was 1.7-fold higher than in the high-TC group after adjustment for confounding variables.
Adjusted all-cause mortality decreased by 0.9% for each 1 mg/dL increase in serum TC and by 0.8% for each 1 mg/dL increase in serum LDL-C.

Structured PICO

Does lower serum total cholesterol concentration increase all-cause mortality in a very elderly (85-year-old) population?

Population

207 community-dwelling very elderly participants (85 years old)

Intervention

High total cholesterol (≥209 mg/dL) or intermediate total cholesterol (176-208 mg/dL)

Comparator

Low total cholesterol (≤175 mg/dL)

Outcome

All-cause mortality at 10 yearshard clinical

In a very elderly population (85 years old), lower total and LDL cholesterol concentrations are independently associated with increased 10-year all-cause mortality.

Cite This Study

Takata et al. (2014) studied this question.

synapsesocial.com/papers/6a703aed2163a0a01bc473cb https://doi.org/10.2147/cia.s53754

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Serum total cholesterol concentration and 10-year mortality in an 85-year-old population

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Serum total cholesterol concentration and 10-year mortality in an 85-year-old population

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider