What question did this study set out to answer?

To quantify the relative contributions of distinct cellular pathways to the uptake and plasma clearance of high density lipoprotein cholesterol esters in rabbits.

January 1, 1991Journal of Clinical InvestigationOpen Access

Evaluation of pathways for the cellular uptake of high density lipoprotein cholesterol esters in rabbits.

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To quantify the relative contributions of distinct cellular pathways to the uptake and plasma clearance of high density lipoprotein cholesterol esters in rabbits.
Simultaneously injected radiolabeled tracers of HDL cholesterol esters, HDL apo A-I, LDL apo B, and VLDL cholesterol esters intravenously into rabbits.
Monitored plasma radioactivity decay curves over 24 hours across four distinct lipoprotein fractions: HDL without apo E, HDL with apo E, LDL, and VLDL.
Over 90% of circulating plasma cholesterol esters originated within the HDL fraction.
Approximately 70% of HDL cholesterol esters were cleared following transfer to LDL and VLDL, 20% cleared via direct selective uptake without intact particle internalization, and 10% cleared as intact HDL particles.

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Implication

In vivo kinetic analysis demonstrates multiple clearance pathways for HDL cholesterol esters in rabbits, indicating a significant role for direct selective uptake in humans.

Cite This Study

Goldberg et al. (1991) studied this question.

synapsesocial.com/papers/6a1078beb6f5ee040160b4be https://doi.org/10.1172/jci114991

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Implication

In vivo kinetic analysis demonstrates multiple clearance pathways for HDL cholesterol esters in rabbits, indicating a significant role for direct selective uptake in humans.

Evaluation of pathways for the cellular uptake of high density lipoprotein cholesterol esters in rabbits.

Key Points

Discussion

Implication

Cite This Study

Evaluation of pathways for the cellular uptake of high density lipoprotein cholesterol esters in rabbits.

Key Points

Discussion

Implication

Cite This Study

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