November 1, 1982Arteriosclerosis An Official Journal of the American Heart Association IncOpen Access

Comparison of cholesteryl ester transfer from chylomicrons and other plasma lipoproteins to aortic intima media of cholesterol-fed rabbits.

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Population

Rabbits fed 0.5 g cholesterol daily for 40-60 days, with plasma cholesterol concentrations between 20 and 30…

Design

Preclinical

Follow-up

1 to 4 hours

Authors

SSSteen StenderSemmelweis University DZD.B. ZilversmitCornell University

Discussion

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Implication

Minimal direct uptake in rabbit models cautions against human extrapolation; leaves open dominant indirect pathways for aortic CE influx.

Structured PICO

Population

Rabbits fed 0.5 g cholesterol daily for 40-60 days, with plasma cholesterol concentrations between 20 and 30 mM (800-1200 mg/dl)

Intervention

Simultaneous injection of lymph chylomicrons labeled with 14C-cholesterol and plasma very low and intermediate density lipoproteins (d < 1.019) labeled with 3H-cholesterol

Outcome

Direct vs indirect uptake of chylomicron cholesteryl ester into aortic intima media and liver tissuessurrogate

In cholesterol-fed rabbits, direct uptake of chylomicron cholesteryl ester contributes minimally to cholesteryl ester influx into the aortic intima media and liver.

Cite This Study

Stender et al. (1982) studied this question.

synapsesocial.com/papers/6a711d04fe4101aa97e0706e https://doi.org/10.1161/01.atv.2.6.493

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Comparison of cholesteryl ester transfer from chylomicrons and other plasma lipoproteins to aortic intima media of cholesterol-fed rabbits.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of cholesteryl ester transfer from chylomicrons and other plasma lipoproteins to aortic intima media of cholesterol-fed rabbits.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider