Key result
In normal fasted rabbits, 70-80% of injected chylomicrons were cleared from plasma in 20 minutes, with bone marrow acting as a major site of uptake alongside the liver.
This study demonstrates that bone marrow perisinusoidal macrophages are a major site for the clearance of triglyceride-rich lipoproteins in rabbits, alongside the liver.
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Should not alter clinical lipid management; leaves open bone marrow's role in human chylomicron clearance.
Hussain et al. (1989) studied Normal fasted rabbits. Injection of [14C]cholesterol- and [3H]retinol-labeled chylomicrons was evaluated on Clearance of chylomicrons from plasma. In normal fasted rabbits, 70-80% of injected chylomicrons were cleared from plasma in 20 minutes, with bone marrow acting as a major site of uptake alongside the liver.
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