What does this research mean for the field?

The liver possesses a specific chylomicron remnant uptake mechanism that is genetically distinct from the LDL receptor, enabling normal chylomicron clearance even in the absence of functional LDL receptors. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 1982Proceedings of the National Academy of SciencesOpen Access

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.

View Full Paper

Ask AI

Bookmark

Population

Normal and homozygous Watanabe hereditary hyperlipidemic rabbits.

Comparison

Intravenous injections of rat chylomicrons… vs Normal rabbits vs. WHHL rabbits.

Design

Preclinical

Authors

TKTomoko KitaKyoto University JGJ L GoldsteinNational Institutes of Health MBMatthew S. BrownUniversity of California, Los Angeles

Discussion

Member takes

Implication

Chylomicron remnant clearance proceeds normally without LDL receptors in rabbits; leaves open existence of a distinct human hepatic uptake pathway.

Structured PICO

Population

Normal and homozygous Watanabe hereditary hyperlipidemic (WHHL) rabbits (which have a near-complete deficiency of LDL receptors).

Intervention

Intravenous injections of rat chylomicrons labeled either in the lipid portion with [3H]cholesterol and [14C]palmitate or in the protein portion with [125]iodine.

Comparator

Normal rabbits vs. WHHL rabbits.

Outcome

Clearance rate of radiolabeled chylomicrons from plasma and accumulation of radioactivity in the liver.surrogate

The rabbit liver possesses a specific chylomicron remnant uptake mechanism distinct from the LDL receptor, allowing normal clearance of chylomicrons even in the absence of LDL receptors.

Cite This Study

Kita et al. (1982) studied this question.

synapsesocial.com/papers/6a1dd08049e88a0d41602c1d https://doi.org/10.1073/pnas.79.11.3623

View Full Paper

Ask AI

Bookmark

Implication

Chylomicron remnant clearance proceeds normally without LDL receptors in rabbits; leaves open existence of a distinct human hepatic uptake pathway.

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider