What question did this study set out to answer?

To review the consequences of maternal prenatal social stress on pregnancy maintenance, fetal development, and offspring neuroendocrine, reproductive, and behavioral phenotypes.

July 30, 2013ReproductionOpen Access

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

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Authors

PBPaula J. BruntonRoslin Institute

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Implication

Narrative review demonstrates prenatal social stress impairs pregnancy outcomes and programs offspring neuroendocrine function, highlighting intergenerational transmission of altered phenotypes.

Key Points

To review the consequences of maternal prenatal social stress on pregnancy maintenance, fetal development, and offspring neuroendocrine, reproductive, and behavioral phenotypes.
Synthesized findings from animal models and human literature evaluating the ethological impact of social stress during distinct pregnancy windows.
Assessed developmental, neurobiological, and endocrine trajectories across gestational stages with emphasis on sex-specific vulnerability.
Social stress during early gestation predominantly leads to pregnancy loss, whereas stress in late gestation results in low birth weight and increased risk for adulthood diseases.
Prenatal stress permanently alters offspring brain architecture, causing hyperactive hypothalamo-pituitary-adrenal axis reactivity, elevated anxiety-like behaviors, and disrupted hypothalamic-pituitary-gonadal steroidogenesis.
Exposed female offspring display programmed impairments in future maternal care, providing a pathway for phenotypic deficits to transmit across generations.

Cite This Study

Paula J. Brunton (2013) studied this question.

synapsesocial.com/papers/6a107e5312e2385ed3fe29fd https://doi.org/10.1530/rep-13-0258

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Implication

Narrative review demonstrates prenatal social stress impairs pregnancy outcomes and programs offspring neuroendocrine function, highlighting intergenerational transmission of altered phenotypes.

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

Discussion

Member takes

Implication

Key Points

Cite This Study

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