What question did this study set out to answer?

To comprehensively synthesize cancer sites associated with more than 100 recognized carcinogenic agents and catalog known and suspected causes across specific anatomical sites using updated IARC evaluations.

December 12, 2011JNCI Journal of the National Cancer InstituteOpen Access

Preventable Exposures Associated With Human Cancers

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Authors

VCVincent James CoglianoCentre international de recherche sur le cancer RBRobert A. BaanIkazia Ziekenhuis KSKurt StraífBoston College

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Implication

Evidence synthesis maps over 100 carcinogenic exposures across human cancer sites, highlighting critical gaps where common malignancies still lack identified preventable causes.

Key Points

To comprehensively synthesize cancer sites associated with more than 100 recognized carcinogenic agents and catalog known and suspected causes across specific anatomical sites using updated IARC evaluations.
Reviewed and extracted evidence from the International Agency for Research on Cancer (IARC) Monographs Volume 100 review series evaluating human carcinogens.
Cross-tabulated more than 100 classified carcinogenic agents against target cancer sites and compiled the mechanistic biological rationales supporting classifications.
Cataloged known and suspected causes across specific cancer sites, demonstrating an increasing reliance on mechanistic biological evidence for identifying human carcinogens.
Identified that epidemiological research continues to uncover new cancer sites and validate carcinogenic hazards occurring at lower exposure thresholds.
Determined that despite decades of carcinogen classification, several common human cancers still lack identified preventable or causal exposures.

Cite This Study

Cogliano et al. (2011) studied this question.

synapsesocial.com/papers/6a1081e1d91177df95fcce2c https://doi.org/10.1093/jnci/djr483

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Implication

Evidence synthesis maps over 100 carcinogenic exposures across human cancer sites, highlighting critical gaps where common malignancies still lack identified preventable causes.

Preventable Exposures Associated With Human Cancers

Discussion

Member takes

Implication

Key Points

Cite This Study

Preventable Exposures Associated With Human Cancers

Discussion

Member takes

Implication

Key Points

Cite This Study

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