Key result
BuYangHuanWu decoction improves lipids and oxidative stress in rat atherosclerosis models by suppressing NF-κB signaling.
Why the study?
Atherosclerosis is a leading cause of cardiovascular disease with high morbidity and mortality, and the mechanisms of the classic Traditional Chinese Medicine prescription BuYangHuanWu decoction in treating it required analysis.
Does BuYangHuanWu decoction improve atherosclerosis markers in an AS rat model?
Population
Atherosclerosis rat model
Comparison
Different amounts of BuYangHuanWu decoction
Design
Network pharmacology and animal experimental study
Authors
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No change to practice warranted; leaves open translation of this rat model to human atherosclerosis.
Does BuYangHuanWu decoction improve atherosclerosis markers in an AS rat model?
BuYangHuanWu decoction ameliorates atherosclerosis in a rat model by improving lipid profiles, reducing oxidative stress, and suppressing inflammation via the NF-κB pathway.
Liu et al. (2019) studied Atherosclerosis. BuYangHuanWu decoction (BYHWD) was evaluated on Serum lipid levels, tissue oxidative stress levels, and aortic intima morphology. BuYangHuanWu decoction ameliorated serum lipid levels and tissue oxidative stress in a dose-dependent manner in an atherosclerosis rat model by suppressing the NF-κB signaling pathway.
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