Why the study?
Does deletion of cGMP-dependent protein kinase I in cardiomyocytes amplify cardiac hypertrophy induced by isoproterenol or transverse aortic constriction in mice?
Population
Wild-type [control] mice, total cGKI-KO mice, and cGKIbeta rescue mice lacking cGKI specifically in…
Comparison
Isoproterenol infusion or transverse aortic… vs Wild-type control (CTR) mice
Design
Preclinical
Follow-up
7 days
Authors
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cGKI deletion does not amplify hypertrophy in these models; leaves open its role in other stressors or human disease.
Does deletion of cGMP-dependent protein kinase I in cardiomyocytes amplify cardiac hypertrophy induced by isoproterenol or transverse aortic constriction in mice?
Deletion of cGMP-dependent protein kinase I in cardiomyocytes does not amplify cardiac hypertrophy induced by pressure overload or chronic isoproterenol infusion in mice.
Łukowski et al. (2010) studied this question.
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